Rehabilitation and clinical observation of stroke patients to validate prognostic factors for functional and subjective recovery after stroke
Recover-S is a long-term observational study of stroke patients conducted at many clinics (multicenter).
With the Recover-S study, we would like to
- Observe the recovery after a stroke via the various stations (acute clinic, rehabilitation, home environment) (“patient journey”)
- Identify factors associated with a positive recovery
- Investigate to what extent the amount and type of rehabilitation therapies have an impact on quality of life after stroke
Background information
In over a third of cases, a stroke leads to permanent physical limitations for the survivors. For this reason, rehabilitation is crucial for the recovery process and its role in social reintegration. However, studies on the effect of rehabilitation and its relationship to the functional recovery of patients have not yet been sufficiently investigated.
What does Recover-S want to achieve?
Our research project pursues the overarching goal of analyzing stroke rehabilitation in Germany through a comprehensive study in various centers in and around Berlin. We want to reliably record the current rehabilitative approaches in Germany. In doing so, we want to include as broad a spectrum of patients of different severity levels as possible in order to obtain a picture that is as representative as possible.
Procedure
Patients are included either as part of the acute event in hospital or as part of a rehabilitation facility (see V1 or V2 below). This is followed by telephone and clinical visits.
Our follow-up at 6, 12 and 24 months after a stroke is intended to improve both continuous care and a post-stroke aftercare concept.
Funding of the study
The Recover-S Register is currently funded by the Corona Foundation in the Stifterverband, as part of a research grant for the “Stroke Prevention and Rehabilitation” working group led by Dr. Alexander Heinrich Nave.
Centers
Charité – Universitätsmedizin Berlin, Campus Benjamin Franklin, Department of Neurology
Local study management
Prof. Dr. med. Heinrich Audebert
Site director CBF
Substitute Prof. Dr. Fabian Klostermann
Charité – Universitätsmedizin Berlin, Charité Campus Mitte, Department of Neurology
Local study management
Prof. Dr. med. Matthias Endres
Clinic Director
Charité – Universitätsmedizin Berlin, Campus Virchow-Klinikum, Department of Neurology
Local study management
Prof. Dr. med. Christoph J. Ploner
Site director CVK
Krankenhaus Bethel Berlin
Department of Geriatrics
Local study management
Dr. med. Sven Schöpe
Chief Physician Neurology
Substitute Dr. Simon Aliaga
Evangelisches Geriatriezentrum Berlin
Local study management
Prof. Dr. Ursula Müller-Werdan, Chief physician
Substitute Dr. Elke Lehmkuhl
Homepage
Medical Park Berlin Humboldtmühle
Local study management
Prof. Dr. Dr. Martin Ebinger
Chief Physician Neurology
Substitute
Carolin Waldschmidt und PD Dr. Alexander Kunz
Jüdisches Krankenhaus Berlin
Local study management
PD Dr. Gerhard Jan Jungehülsing
Chief Physician Neurology
Substitute Dr. med. Dávid Vadász
Vivantes Auguste-Viktoria-Klinikum
Local study management
Prof Dr. Bruno-Marcel Mackert
Chief Physician Neurology
Substitute Mara Gavrila
Vivantes Auguste-Viktoria-Klinikum
Neurologische Rehabilitation
Local study management
Dr. med Nils Banthien
Chief Physician Neurology
Brandenburgklinik Berlin-Brandenburg
Local study management
Prof. Dr. med. Felix Schmidt
Chief Physician Neurology
and
Dr. med. Elke Kretzschmar
Chief Physician Neurology
Interested?
Would you or your institution like to act as a participating center? Please contact us via our contact form
Recruitment rate
Cohorts
The Recover-S Registry can be used to investigate specific research groups in individual defined stroke groups (cohorts). Here we provide an overview of already defined cohorts. Further cohorts may be added in the course of time.
Rehabilitation Cohort
The aim of this cohort is to determine the relationship between stroke rehabilitation therapies and long-term functional and subjective outcomes in terms of timing, duration, dosage and extent of stroke rehabilitation. Consistently relevant data will be collected from the included patients using clinical tests and questionnaires, an examination and existing routine data. This cohort is intended to reflect the current standard of care in stroke rehabilitation.
Biomarker Cohort
An additional blood sample and magnetic resonance imaging (MRI) of the brain will be performed on a proportion of the included patients, the so-called biomarker cohort. The aim is to determine laboratory chemical biomarkers (e.g. inflammation parameters) and imaging characteristics (e.g. size and localization of the stroke) that are suitable for predicting recovery after stroke and the individual response to certain rehabilitation therapies. Recruitment for this cohort is currently taking place exclusively at Charité, Campus Benjamin Franklin.
Further cohorts will be defined in the course of the study period.
Unterstützer
